1) Load class pointer from object movq (%rdi),%r11
2) Load cache pointer from class movq 0x10(%r11),%r8
3) Load cache entry (IMP) from cache movq 0x10(%r8,%rcx),%r11
4) Load function pointer from IMP movq 0x10(%r11),%r11
Notice that each of these loads reads into a register which is then treated as an address by the next load. This does a great job of totally stalling your pipeline while you wait for memory reads. I've been staring at this same grim pattern in the profiler since the days of PowerPC.
C++ virtual function calls are doubly-indirect in the worst case (read vtable pointer from object, read function pointer from vtable). And because it's emitted at the call site and not hidden in a function, the compiler can often reduce it down to singly indirect or even direct link it as a static call, if it can prove the exact type.
Objective-C is not as bad as some say, but if your code is highly optimized, method call overhead can become a bottleneck.
It's also very much like calling a virtual function in C++, only slower.