We are still at a point in Biotech where companies have to do fundamentally new things with their tech to succeed. If you were starting a company that applies CRISPR to X genetic disease, you might not need a Ph D. to start the company, because you can apply existing technology to solve that problem. But that begs the question: Why has no one else done it yet?
At the end of the day, you need a unique insight to start a large company. That means experience with either the problem space or the technology space is helpful. Not discouraging OP either, if you have a vision for what the future should look like, and can acquire talent/capital... anyone can start a massive company. So OP should try to acquire that vision.
But there's no doubting that some sort of counter-intuitive or hidden insight is necessary. Even if that insight is: "people think this is obvious and not worth doing, but it actually IS worth doing." RE: Zero to One.
To found a company? How do you know where to start? If you are hiring PhDs to come up with the idea for you, how do you if their ideas are novel or worthwhile?
Not to disparage SaaS founders, but I think it's somewhat easier to look about and say "there is no app for sending texts via REST API" and do that, than it is to look at say "no one has found a way to selectively target cancer cells for CRISPR" and then go do that.