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Re:Design for Hackers: Why You Hate Comic Sans by skermes on Tuesday January 25, 2011 @11:47AM (#2139707)
People with dyslexia apparently find Comic Sans substantially easier to read than many other common computer fonts: http://www.dyslexic.com/fonts

It would be interesting to have something similar to CSS media queries for screen size for accessibility flags. Making it easier to change fonts for dyslexic people or color schemes for colorblind people would be great.

Re:Design for Hackers: Why You Hate Comic Sans by jacobolus on Tuesday January 25, 2011 @12:12PM (#2139842)
Your summary is much more emphatic (“people”; “substantially easier”) than any of the research I’ve seen.

As for color schemes: any scheme which makes a website unreadable by the color blind will make it mostly unreadable by everyone else, too: human vision distinguishes shapes and details mainly via lightness contrast.