It's all a spectrum, but generally speaking, Web Frameworks are for Apps (Gmail, Facebook Ads Manager, etc.) and HTML/CSS sites are more for presentational pages, etc. The big problems come about when you try to cross those bounds.

At the extremes, you either end up with thousands of lines of spaghetti code or an over-engineered mess serving up a html page with a single image on it.

Web frameworks are just a tool that needs applied to the right job.