Prenatal THC exposure yields hyperdopaminergic phenotype rescued by pregnenolone

Re:Prenatal THC exposure yields hyperdopaminergic phenotype ... by notafraudster on Wednesday October 23, 2019 @02:09PM (#21337227)

2mg/kg subcutaneous. I don't know the conversion between subcutaneous and other forms of ingestion, but this would be equivalent of ~150mg of THC for an adult male. I also don't the THC content of weed, but it doesn't sound like an unfathomably high dose. I think the other design concerns are more likely to be the culprit here than external validity worries about dose.

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Re:Prenatal THC exposure yields hyperdopaminergic phenotype ... by jjjensen90 on Wednesday October 23, 2019 @02:24PM (#21337353)

Normal weed "flower" is 10-30% THC. So 1 gram of weed is 100-300ish mg of THC. A single prerolled joint is usually 1 gram of flower. So this dose is around 1 joint.

Edit: importantly this info is for smoked flower, edibles and concentrates are a little different because of how they are absorbed.

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Re:Prenatal THC exposure yields hyperdopaminergic phenotype ... by loeg on Wednesday October 23, 2019 @02:45PM (#21337556)

Smoking an entire 1g preroll by yourself is a huge dose for a human who doesn't have a high tolerance.

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Re:Prenatal THC exposure yields hyperdopaminergic phenotype ... by filoleg on Thursday October 24, 2019 @01:31PM (#21346972)

I mean, it would depend on the THC concentration, right? A 1g pre-roll with 30% THC would be 3 times as potent as the one with 10%, so I can totally see someone with rather low tolerance smoking a full 10-12% joint by themselves and feeling just fine.

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Re:Prenatal THC exposure yields hyperdopaminergic phenotype ... by pault on Wednesday October 23, 2019 @02:44PM (#21337545)

There is a scaling factor between mouse and human dosage that I can't remember off the top of my head, but it's not 1:1.

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Re:Prenatal THC exposure yields hyperdopaminergic phenotype ... by Pete_D on Wednesday October 23, 2019 @03:17PM (#21337864)

Looks complicated. https://en.wikipedia.org/wiki/Allometry#Drug_dose_scaling

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Re:Prenatal THC exposure yields hyperdopaminergic phenotype ... by pault on Friday October 25, 2019 @01:14PM (#21357065)

Whoops, yeah. I meant linear, not 1:1.

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Re:Prenatal THC exposure yields hyperdopaminergic phenotype ... by eisrep on Wednesday October 23, 2019 @02:23PM (#21337349)

Just for reference, your average edible will come in a suggested dose of ~10mg THC per piece.

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