The Witness, mentioned up-page (at time of writing—will probably stay there, given the author) is great and a bit Mystish, though with a very different sensibility re: puzzles. There's also The Talos Principle, which is kinda Myst+Portal.

I didn't like Portal 2's official single player campaign as much as the first Portal, but the two-player coop mode is excellent, and a rare example of multiplayer puzzling.