Or just Apache. Apache serves static content faster than the vast majority of us will ever need, and dynamic content as fast as Lighttpd or nginx, in general (because the slow part is the code in Python, or PHP, or Ruby, or Perl). Run WSGI or mod_fcgid or mod_rails, or whatever, so your interpreter only spawns once, configure Apache appropriately, and you'll be fine for all but the most insane loads.