There's a lot of people in this hobby that use Dvorak, and the other obscure layout that I don't even remember the name of. Some even design and sell PCBs/entire kits for them. Most of the keyboards seem to use QMK, an open source, programmable firmware so you can do whatever you want.

There's a lot of debate on those layouts and their usefulness. There's people that swear it saved them from RSI and there's people that say nothing can be proven about the health benefits of any alternative layout. There are a lot of people that switched to an alternative for a few weeks, months, or even a year and then went back to qwerty. I've stuck with qwerty so I don't have a lot of knowledge on the subject.