Well, it's dystopian sci-fi. Of course there's got to be some way to hit back against the oppressors.

On the other hand, if your battle plan involves using up an entire truck for each enemy soldier (or squad?) neutralized, I feel like you're gonna have a hard time scaling that up to open warfare.

With the number of Ford F-150s in the US (or Toyota Tacomas in the Mid-East), it scales reasonably well when either used for targeted assassination of High Value Targets, or as the opening barrage of a combined-arms attack. Considering total costs of employment (vehicle modifications, including explosives), it's cheaper than air support and more accurate than traditional tube artillery.