Better; use dvtm within Screen. This is what i do; one Screen session (fullscreen size) on my main dev box with each Screen window running its own dvtm instance. Thus each Screen window becomes a "workspace" (if needed, connected to a remote host) with dvtm-managed multiple tiles/shells. Flexible and not too complicated with all the power of Screen and the simplicity of dvtm. In fact, i use this setup even when working on my local machine. Throw in vim for the editor and you have a simple and standard setup which you can carry with you everywhere.

I appreciate the simplicity of abduco when saving sessions of already TUI-intensive programs like MUD or IRC clients.

When starting my GNU Screen journey 10-ish years ago, I immediately switched the meta key to Ctrl-K, which I had never used for anything in any app up to that point.