py2exe and anything else that uses Joachim Bauch's memory loader is loading DLLs in a broken fashion that is bound to bite you sooner or later, assuming it works in the first place.

Reimplementing - in a buggy incompatible way - the Windows loader (which is what that code is doing) from scratch, is a gross hack and should not be used to build anything that's meant to be reliable.

Note that pyinstaller and cx_freeze do not suffer from these issues. Do not use py2exe.