I, personally, prefer Ruby because it thinks the same way I do (if that makes sense). So that's what I'd pick. But Python would do you just as well, if you like the way it reads, etc. better. They key, I think, is to not be too worried about speed up front. Get your thing working in Python, say, and then do testing (another comment mentioned this) and rewrite what's slowest in C. I guess I'm warning against premature optimization.