It goes out to all the cloudfront edge locations so that generally isn't an issue. That being said anything under 300ms is not going to be very noticeable to most people.
Contemporary fancysites might pull up a skeleton in that time, but it'll (often) take multiple seconds for every div to be populated and third-party request to return, juggling the page the whole time.
"Initial request to clickability" is definitely longer than it used to be.
Is that in a single location? If so, then it's not really impressive. A good website loads fast even when the client is on the other side of the globe.