Organic, GMO, dsRNA or whatever, pesticides are overused and modern production systems are the problem. Typical modern farming kills the soil and everything on it. Pesticides just speed it up, directly and as an enabler.

As an example without soap, a friend has a garden. Call it holistic, permaculture or whatever. The same plants grow twice as big in his garden compared to neighbor's, because he tends to the plants, the soil and the garden using modern knowledge. No spraying. Lots of mulch, diversity, planning...