I’d really love it if HN allowed me to save in my profile a simple “hide from me” list of domains, so I could say just don’t show me wsj.com, nytimes.com etc.

That would be a good feature request. At the same time, I have found WSJ to be a really valuable source of lightweight tech news as well as a few in-depth tech articles, and they regularly run promos where you get three months for a couple dollars.