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Re:How Biotech Startup Funding Will Change in the Next 10 Years by dekhn on Monday August 05, 2019 @02:43PM (#20617108)
My feeling is that OpenTrons and similar systems would be a cost-effective way to scale up to warehouse-scale high throughput biology with more control over the process automation, making it easier to (for example) upload all the generated data to a large cloud and do large-scale machine learning and analysis over it.

The model I like is basically the same as how Google scanned so many books so fast and cheaply- rather than buying the Hamilton equivalent, they built their own crappy scanners and trained the techs to deal with the crap. This was much more cost effective and scalable. but you need a ton of inhouse experts to deal with the crap hardware, and most large compannies don't want that- they just want a service that works.

Re:How Biotech Startup Funding Will Change in the Next 10 Years by iso1337 on Monday August 05, 2019 @06:11PM (#20619638)
I’ll give your analogy a try.

Google could do that because the basic components were so cheap due to consumer imaging.

On the lab side, there’s no similar downward pressure for making more accurate automated pipettes cheaper - I fully believe it’s possible, but the market isn’t there. Also, with imaging books, you can get away with a lot since ML/cheap labor/etc can be thrown at the distortion correction problem. With lab tests, you can’t really accept that same amount of error (ok, you can iff you understand the distortion and can process more samples to compensate).

I do agree that most companies just want a service that works. The issue is that there’s no standardization. Depending on the assay you do, you will need wildly different setups and sensor systems. When you optimize whatever you are doing, often you have to re-tune your entire assay to bring it line with the new dynamic range of your output.

If that weren’t the case, companies like Emerald and Transcriptic would have succeeded years ago.

Selling things like DNA or cell lines have been the closest to a standard, scalable product. Otherwise, it’s just replacing armies of people at a CRO (Contract Research Org) with a custom project for automation and assaying (Zymergen’s model).

Re:How Biotech Startup Funding Will Change in the Next 10 Years by dekhn on Monday August 05, 2019 @08:39PM (#20620870)
At least in the area I work in (ML on fluorescence microscopy images used to estimate cellular and molecular phenotypes), the problem is extremely similar to the book reader that Google made. Heck, when I worked at Google I even built (20% time, open source) a prototype that could easily have been improved into what I describe (https://github.com/google/cncmicroscope-cad). We have to do the same kinds of distortion corrections (well, actually ours are far harder to do properly) to make the images useful for ML.

I've always been sad that Emerald and Transcriptic haven't been insanely successful. I've tried to put my scopes into both systems (I know the founders), but never made any headway. I like OpenTrons better, but having spent enough of my time knee deep in tubing and stepper motors, I have more appreciation for well-engineered systems.