To me, the only syntax type I dislike more than tons of parentheses is significant indentation. But with s-expressions that's a presentation issue that can be solved with proper formatting and de-emphasising the parentheses visually, whereas significant indentation to me feels actively programmer hostile.

But while I also don't like the appearance of significant indentation, if it was just a presentation choice of an underlying more robust representation, I'd be fine with that.

So I sort-of agree - it seems like something that could be a neat editor plugin etc. on top of a s-expression based language and would be better for it than as the only/default syntax.