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Re:Meli email client, pre-alpha release by OJFord on Monday July 08, 2019 @07:16AM (#20381723)
There's also Mailpile, which is GUI (webapp) but FOSS self-hostable.

https://github.com/mailpile/Mailpile

Re:Meli email client, pre-alpha release by rightos on Tuesday July 09, 2019 @10:08PM (#20398634)
How's the multi-account and desktop notification support in it? I can't find a lot of details on what it does, but there's a mailpile-desktop package that seems potentially promising?