There are generally some more educated pockets within these regions that are actually quite desirable, but lack economic development. These spots, like Asheville NC (the place I ultimately would like to settle down in) are unfortunately quite expensive due to low housing supply and people from out-of-state moving in. But I've got a remote gig now, so I just need to save up more. Personally, I will be happy to be part of a culture that values friendliness, ingenuity, sweet tea and banjo music.

Fwiw, I tried moving away to Seattle, but despite my educational attainment and liberal leanings, I found that I just prefer NC. There's something to be said for living somewhere you don't feel like an outsider. After 5 years in Seattle, I still couldn't lose that feeling.