THC's anxiety inducing effects are (at least in part) caused by CB! receptor activity in the right amygdala. "Fourteen healthy males were studied with fMRI twice, one month apart, following an oral dose of either delta-9-THC (10 mg) or placebo, while they performed a fear-processing task. Baseline availability of the CB1 receptor was studied using PET with [11C]MePPEP, a CB1 inverse agonist radioligand. Relative to the placebo condition, delta-9-THC induced anxiety and modulated right amygdala activation while processing fear. Both these effects were positively correlated with CB1 receptor availability in the right amygdala. These results suggest that the acute effects of cannabis on anxiety in males are mediated by the modulation of amygdalar function by delta-9-THC and the extent of these effects are related to local availability of CB1 receptors." https://www.nature.com/articles/s41598-017-14203-4
Would be interested to study if there is a difference in fear response in sober thc users and non-users. Does 'tolerance' of THC entail amygdalar CB1 downregulation? Does this have measurable effects besides intoxication-related anxiety?
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Anxiogenic effects in rats are greater in adults than adolescents https://www.ncbi.nlm.nih.gov/pubmed/17211649
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"Guiaol, eucalyptol, γ-terpinene, α-phellandrene, 3-carene, and sabinene hydrate all have significant correlations with decreased anxiolytic activity." (Certain strains may have constituents which increase anxiety - many of these have distinctive smells) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204402/
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CBD is widely regarded as safe - this study raises some concern. Could chronic CBD use could possible cause upregulation of amygdalar CB1?
Anxiogenic-like effects of chronic cannabidiol administration in rats https://www.researchgate.net/publication/51798464_Anxiogenic...
People really need to stop repeating this. There are pure cbd sativas just as there are pure cbd indicas. There is no definition for what a sativa/indica is besides what the leaves look like. There's no bearing on subjective high and strains. What people are experiencing is differing THC/CBD ratios.
All of the indica and sativa flower that I purchase is 0% CBD, yet I can most definitely tell the difference. It has nothing to do with the amount of CBD in it.
So yep, dosage is extremely critical with THC.
Do you have any reference to back that up? I ask because I am genuinely curious. I haven't heard this before, and usually with most other drugs the opposite happens, i.e. you slowly build a tolerance that requires taking higher does to acheive the same effects.
Check out the P450 group of enzymes to find out how this works, part of the clearance rate is controlled by the liver becoming more efficient and altering your food and drink cravings.
Other foods/chemicals like grapefruit juice slow the metabolism of some drugs, so 2litres of grapefruit juice combined with 50Mg of viagra will see you visiting A&E with a 5hr priaprism, that has to be let down with andrenaline injections into the corpus spongiosum.
Generally if you want your illegal drugs to last longer dont smoke.
However, it doesn't take much for me to cross that threshold where it can make me extremely paranoid. Usually this is what I call the "will I be stuck this way forever" threshold, where I get stoned to the point where I start to freak out that I will never be able to think clearly again.
So my point is that, at least for me, it is dose dependent, and I could easily imagine a scenario where CBD can act to relax your nervous system responses but not alter your thinking to the point of it becoming a foreign and potentially scary experience.