Absolutely true. I once had to set a client-server Windows-based CRM in a small company. The server had a native Linux version, the client app was windows-only. Client machines ran Windows. Users also wanted to work from home. For some reason (some kind of connection glitches or whatever, I can't remember already) I've chosen to install Xfree on the Ubuntu server (one of command-line-managed VirtualBox VMs on another Ubuntu server actually), set-up the app for direct client-server connection, let users connect to the Linux box over OpenVPN and run the Win32 app with Wine over SSH on their Windows machines :-)
I've fell in love with the X as I have managed to set this up (quite easily, BTW). I certainly don't want Linux to loose such a beautiful ability as it switches to Wayland (I don't worry much about Wine though, all the distributions but Ubuntu keep shipping multiarch libs and it works just fine but I won't update my Mac as it has just 128 GiBs SSD and I have no disk space to spare for a Windows VM).
why? all Intel chips currently supports 32bit ISA. You can still have VMs to run 32bit. also IIRC, Wine is X-Window? so you can even attach through SSH-X to it with simple Docker container.