There are some tech-related employers in Nashua but it's mostly fizzled in other small NH cities like Portsmouth. I think there may have actually been larger tech employers in NH a couple decades back when all the Rte 128 computer companies had a fair number of locations scattered around southern NH and Maine.

Honestly though I'm not sure the commute situation with southern NH is really all that different from people commuting from the further flung Massachusetts suburbs/exurbs into either the city or the closer-in Rte 128 ring where companies are more concentrated.