iTerm is amazing when using many spaces because of the hotkey overlay.

Projects and project parts are separated via spaces but I never want to have to find the right terminal for a process, instead I use a single window with animations disabled (to show immediately) and excluded from app switcher via settings so that it will only ever show up when i press alt-space no matter which space I'm on.

Together with tabs and native panes it works just great and requires very little setup