Evidence of a nocebo response following a nationwide antidepressant drug switch

Re:Evidence of a nocebo response following a nationwide anti... by beowulfe on Sunday June 02, 2019 @03:51PM (#20077652)

On the other hand, sometimes there are significant differences between generic and brand name formulations. For example: https://www.fda.gov/drugs/postmarket-drug-safety-information...

I wonder how many patients had their complaints written off for the six years the generic was on the market?

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Re:Evidence of a nocebo response following a nationwide anti... by dontknowme on Sunday June 02, 2019 @07:04PM (#20078984)

Absolutely, even when the active compounds are the same but there are changes in composition.

For instance, I'm an asthmatic and I need to use a spray inhaler. The no-brand equivalent is exactly the same, and does work the same in normal circumstances, except has roughly 1/2 of the propellant. But I can tell you that the missing propellant makes all the difference when you're having a stronger attack and cannot inhale.

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Re:Evidence of a nocebo response following a nationwide anti... by nerdponx on Sunday June 02, 2019 @09:50PM (#20079810)

I wonder how many patients had their complaints written off for the six years the generic was on the market?

Or who didn't even bother reporting their complaints in the first place.

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