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Re:ProtonMail Voluntarily Offers Assistance for Real-Time Su... by freehunter on Wednesday May 29, 2019 @01:03PM (#20042634)
As long as you never send any emails to anyone who uses Gmail or Yahoo or Outlook etc.
Re:ProtonMail Voluntarily Offers Assistance for Real-Time Su... by groovybits on Wednesday May 29, 2019 @01:07PM (#20042687)
Both Thunderbird and Outlook have plugins for PGP and S/MIME. You can use them to read/send mail from Gmail and Yahoo domains as well.

Edit:

If you're using them for an organization that uses Exchange/O365, the admin would need to make sure IMAP/POP protocols are enabled over TLS/STARTTLS, as opposed to using EAS. However, if you're dealing with mail in an organization, you're probably not using your own encryption keys to being with.