For more on this, see KConrad's comment https://matheducators.stackexchange.com/questions/16636/is-t... and kcrisman's comment https://matheducators.stackexchange.com/questions/16636/is-t... on the post linked by your parent.
Also, the series 2^(2^n)+1 grows extremely quickly; the next number is 18446744073709551617 = 274177 * 6728042131072, and after that 340282366920938463463374607431768211457 = 59649589127497217 * 5704689200685129054721.
For Fermat numbers 2^(2^n) + 1, it is well known that every prime factor should have the form k 2^(n+2) + 1. The sequence (A007117) thus goes like: k = 5 for n = 5 (Euler in 1732, very managable), k = 1071 for n = 6 (Thomas Clausen in 1854) and k = 116503103764643 for n = 7 (only known in 1970 after the modern computer).
π(2^16)=6542: if you told me in elementary school that I might disproving something famous I can see myself working on that for a couple of hours daily for a week or so.