Also wanted to plug "Shen" here, an offshoot of the lisp-based Qi language. Shen is VM agnostic, so it will run on Python, Clojure, etc. Javascript is its first target.

Here is the appeal by its creator - Mark Tarver (and Carl Shapiro)

http://www.lambdassociates.org/Shen/appeal.htm or http://news.ycombinator.com/item?id=1921347

The qi syntax was previously posted on HN : http://www.lambdassociates.org/Book/page000.htm