It depends on how many large suppliers want one vs another. If you can bring in enough revenue to justify the man-power to make the platform change, and you have a feeling it's not a one-off job, then do it.

I am currently facing the same dilemma, in that we normally license our software as a javascript client side library to add functionality to an existing site or one being developed. However, someone wants a "replica" of our site, but branded and translated to a different language, including our profit model. It's only worth pursuing this revenue if they pay us enough to offset the work required. If/when it is done, I can rinse/repeat MUCH easier, and I have another avenue for monetization aside from our existing two.

So, very situational and only can be answered by you...