Who the advertisers might want to reach is relevant because FB can currently promise to do whatever is practically possible to block ad blocking. This doesn't amount to much (tricks like the extra divs littered through the word "sponsored" and so forth, to obfuscate the advert related code & markup from blocking scripts, for instance) but is better from the advertisers point of view than them admitting it is going to happen and they've given up stopping it. And again, the official ad blocking method is likely to make unofficial blocking easier - they would have to defend that to their advertising customers.
The other issue that could come up is effectively creating a two tier system, with those that can afford to pay and those that can't. Equality and privacy defenders might be all over that, and however right or wrong people think each side would be there FB are not going to want that on top of all the public scrutiny they are already getting.
That advertisers might want to reach me isn't especially relevant, because there's no situation under which that is a possible outcome for fb.