Inflammation might be the root of preventable disease

Re:Inflammation might be the root of preventable disease by refurb on Wednesday April 24, 2019 @08:08PM (#19743774)

Yup, and anti-oxidants actually prevent aerobic conditioning in athletes.[1]. Presumably oxidative stress is a signal to the body to become more aerobically efficient.

Yet at the same time, oxidative stress is linked to numerous diseases.

Biology is hard.

[1] Derek Lowe’s blog (don’t have exact link)

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Re:Inflammation might be the root of preventable disease by aeternus on Wednesday April 24, 2019 @08:25PM (#19743843)

It's almost as-if our cells depend on some sort of chemical equilibrium. The old advice of everything in moderation may be the best way to go.

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Re:Inflammation might be the root of preventable disease by perl4ever on Wednesday April 24, 2019 @08:29PM (#19743865)

"Biology is hard" doesn't really express what I think people don't get about biology (granted I'm not a biologist).

With everything complex, not just living creatures, the real problems are caused by failure to maintain a negative feedback loop properly, and pushing on it doesn't help because the negative feedback is still there almost the same way as normal and has to be to avert complete disaster.

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Re:Inflammation might be the root of preventable disease by lugg on Wednesday April 24, 2019 @09:04PM (#19744041)

I'm not sure your explanation was any easier to grok for people, how about this:

Inflammation is what the body uses to clean out disease and heal itself.

The individual mechanisms used to do this could be considered analogous (but very different from) a short antibiotics regimen.

In the short term or localised to one area it is beneficial. But at a systemic always on level there are negative side effects where these systems begin to overwhelm/damage healthy functions/cells.

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