Behind the Buzz: How Ketamine Changes the Depressed Patient's Brain

Re:Behind the Buzz: How Ketamine Changes the Depressed Patie... by temp2903d on Friday April 12, 2019 @11:58PM (#19651044)

250mg seems exceptionally high (in reference to the OP's response below). The esketamine nasal spray that was just approved contains only 28mg per dose (1-2x/week). I don't know if that's because you need more if you take it sublingually. Snorting/nasal is almost certainly the most efficient/most effective way to take it.

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Re:Behind the Buzz: How Ketamine Changes the Depressed Patie... by atomical on Saturday April 13, 2019 @12:21AM (#19651108)

1) The different ROAs have different bioavailability.

2) Ketamine is cheap. Convenience should be prioritized over efficiency.

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Re:Behind the Buzz: How Ketamine Changes the Depressed Patie... by throwaway0x69AF on Saturday April 13, 2019 @09:18AM (#19652840)

It's not just about the expense, ketamine can damage liver and kidneys, and reduce iron uptake. Efficiency, in this case, is more about harm reduction than expense

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Re:Behind the Buzz: How Ketamine Changes the Depressed Patie... by atomical on Saturday April 13, 2019 @10:28AM (#19653185)

I've read some of the most important papers and books and have never come across this. Please post a source.

Depression is a very serious illness and ketamine is a very safe drug. We need to give people more options.

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