“Before you diagnose yourself with depression or low self esteem, first make sure you are not, in fact, just surrounded by assholes.”

Change your environment and habits if you can. Go outside more, preferably somewhere with greenery and wildlife. Parks are great, places with few people are even better. If you don’t have an exercise habit, try and build one. Do things you enjoy. Hang out with people you like. If you can combine the two. Consider seeing a therapist or getting on SSRIs or done other drug. If you don’t see much of the sun you could just need more sunlight.

Read old philosophy on how to live the good life and apply its lessons as much as you can, whether it’s Seneca, the Enchiridon, Lucretius, Confucius or Xunzi. You are not alone and others have wrestled with these feelings. You can wrestle with them by yourself or you can do so with the help of those long dead, professionals, family or friends.

If your work feels meaningless and you want more meaning seek it out. Do work that means something. 80,000 Hours has a job board for people who want to do things that matter in their life and want to help people, lots of people. If that floats your boat look at their job board.

https://80000hours.org/job-board/