Yeah I used to have a 2-28" side by side with a top 28" on arms and I really didn't like it. It caused constant neck pain no matter how I adjusted my seating position and I wound up rarely even using the top monitor. I initially figured I'd just keep spotify/media on it
Back to 2-28s now. Debating on getting 1 49" but I'm worried I'll miss having two completely separated monitors.
The ideal position of a monitor is with the top directly in front of your eyes when your head is perfectly upright.
That said you obviously don't have to turn your head as much, which might make up for that.