I have no CS degree either and mostly found that this isn't an issue with technical interviewers, BUT there is one place where it does matter: USCIS requirements for high tech work visas requires either a degree or "equivalent" work experience. I happen to have well over a decade of work experience under my belt and was able to get my work visa thanks to that, but this is definitely a real barrier if you're outside of the US and your goal is to get a silicon valley career.