A more reasonable case is that they can heavily influence what contractors and 3rd parties are used for projects. Not something that needs a board vote, but something a 40% shareholder has a lot of say in.
The literal thing I just said isn't even that unethical; suppose you own 100% of a company, then telling it to hire someone specific and pay them this much and put them here would be fully within your rights as owner. (There's probably a legal hurdle or two to clear, but AFAIK it's nothing that will actually stop you.) How that changes ethically as your ownership stake decreases I'll leave as an exercise for the reader. What's unethical is what they'll be doing when they get there, and who else is tainted ethically depends on how much they know and what they do about it.
This depends a lot on who owns the other 60%. If it's one other party, the 40% effectively has no control. If it's a public company with a million other owners and they're the largest individual shareholder, many of the others won't even show up to vote their shares and their 40% of all shares will generally be >50% of the ones that show up to vote for anything.