The immune system is the best analog. Lack of exposure to the things with the potential to harm you makes you far more susceptible to legitimate harm. But a compromised system is a compromised system, and should be treated as such; the healthy dose of exposure is not the same for everyone.

I would say that the problem with the current milieu is a matter of magnitude, or lack thereof, as it puts very little value in the utility of any exposure whatsoever, and far under-qualifies the necessary criteria for a compromised system.