Appleseed is fully themable using CSS, and keeps a clear separation between logic and presentation, so any designer can make it look any way they'd like.
However, if you're speaking more to the actual user interface, I'd be very interested to hear your thoughts on what you find to be an issue.
I used MS Paint to make a few edits: http://yfrog.com/eodesign0j
The startup I am at has gone through 16 completely redesigned home pages over the course of a year before landing on the one we're at now. We are always asking ourselves what could be improved and watching User Fly videos to see where users are getting confused. I'm only trying to provide food for thought to improve and enhance your product; a product that is off to a great start.
One problem with any Facebook alternative where you have just one "reference application" implemented is that people will glance at the page and judge it by looks regardless of how configurable it is. That's a problem with any UI sadly enough.
I guess that's why I like the idea of creating layers and protocols to allow easy, multiple implementations. IE, my idea of five minutes ago - plugins for Drupal, Wordpress and Phpbb to ties multiple sites into a single large social network. The issue of design might then not be front-and-center.
So there's no reason I couldn't implement a radically different UI like this without changing any of the base code. Theoretically, you would even be able to switch between the UI's with a simple button.
http://www.behance.net/Gallery/Facebook-Facelift-Home-Profil...
Do you have to use php?