Well yeah, OS packaging formats are for putting together your build artifacts. You can use whatever to build the software.

If you want to do it 'right' you would use pip to build packages for any missing runtime dependencies from your OS repos and the package your application. I swear it's much easier than it sounds.

But nothing says you have do it like an OS maintainer though. You can also just vendor all your dependencies, slurp them all up in an RPM and install in /opt.