Another vote for Hazel. I also use Yoink, which is sort of a drag-drop shelf for files that you're trying to move from one place to another. Drag them to the Yoink shelf, go do some other stuff, then drag them off of the Yoink shelf to their destination. For screenshots and images I'm saving on the web, I no longer even allow them to save to the desktop. I perform the screenshot (or drag from browser), drag it from the new Mojave preview widget to Yoink, then drag them to the destination. They're never saved in Downloads or on my Desktop.