I use FLAC for storage, and Opus for playback. I.e. in essence I use both. The benefit of lossless is ability to re-encode later to any new codec (Opus-next?) if it will be useful. For playback, transparent Opus is good since it takes less space.

I.e. in practice - in my main archive I use FLAC. On some portable players and etc. I use Opus encoded from that FLAC.

That's why I always try to buy music in FLAC when possible and stores like Bandcamp are great for it.