The backend is much better for clients than Django in my opinion, though personally I prefer Django.

As for multiple sites, there's an extension called the multi-site manager that allows you to control multiple sites through the one admin interface, which makes it much easier for our clients, all the different sites appear in a list and they can select which one to edit, then move on to the next.

We use the latest version and yes it means a few plugins aren't compatible, but they're catching up quickly and they're actually easy to update yourself if it's necessary and legal.