These things are most useful for research via numerical simulation. The uses that would come closest to aiding for-profit endeavors would probably be various simulations of systems still in the design-phase. For example, simulation of a car crash, simulation of aerodynamics of an automobile or airplane, simulation of the fluid dynamics of a jet engine, simulation of hydrodynamics of a new super-tanker design, etc.

Such simulations are fairly common today, although generally super-computers of this magnitude aren't needed for them.