I wasn't going to mention qutebrowser[0] since I didn't think it was relevant, but it works well. Most of the keys in the browser can actually be rebound. With keyboards like I mentioned, the additional keys can be mapped to special key combos like `Alt+Shift+D` to avoid collisions.
It's also possible to map most or all of Chrome's (not sure about other browsers - but we're talking within the enterprise) keys can be rebound. Check out keycode.info - every key even ones like `Alt+D` and F1 and even `Ctrl+R` can be rebound and prevented from doing their normal function in place of something else!
Personally, I’ve never used a web app that I actually liked or trusted. Maybe it’s just me, but I’m always worried the page will time out or refresh or something.
Like imagine emacs or vim in a browser window, it would be horrible!