Re:‘Trojan horse’ drug treated British patients with six dif...
by twic on Sunday February 10, 2019 @07:02AM
(#19127457)
> This antibody binds to 'tissue factor' which are present at high levels on the surface of many cancer cells. Are these tissue factor present in significant proportions on other types of cell?
Tissue factor is expressed on the surface of the cells adjacent to blood vessels, so it's all over the body.
Tissue factor's normal role is to trigger blood coagulation - it reacts with factors in the blood to trigger a coagulation cascade. There is a waterproof layer of endothelial cells between the adjacent TF-bearing cells and the blood itself, so this only happens when a blood vessel is breached by mechanical damage, letting blood come into contact with TF - the resulting coagulation seals the breach. It's a cool system! Although a bit complicated:
Tissue factor is expressed on the surface of the cells adjacent to blood vessels, so it's all over the body.
Tissue factor's normal role is to trigger blood coagulation - it reacts with factors in the blood to trigger a coagulation cascade. There is a waterproof layer of endothelial cells between the adjacent TF-bearing cells and the blood itself, so this only happens when a blood vessel is breached by mechanical damage, letting blood come into contact with TF - the resulting coagulation seals the breach. It's a cool system! Although a bit complicated:
https://diapharma.com/coagulation/
I had no idea there was a connection between coagulation and cancer, but apparently there is - specifically, it's involved in metastasis:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151023/