You can try. I mount .cache as tmpfs. You need at least 500mb for your browser alone.

Browsers tend to work fine. Some apps just fail badly like rofi (command history stored there oof)

For what it's worth I also tmpfs+asd .nvm, .npm, and */node_modules, without any major headaches. I did have to fix a couple minor pathing dramas but nothing too drastic.

You can export XDG_CACHE_HOME=/tmp