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Re:Consumption of a dark roast coffee blend reduces DNA dama... by max76 on Tuesday January 15, 2019 @11:08PM (#18918163)
I really hate bad science, and this is an example.

Springer Science+Business Media (the publisher) does not transfer copyright of the paper from the author to the publisher like many other journals. This begs the question, why isn't this article open access? The primary author, Dorothea Schipp, is a statistics consultant in small town Germany [0] not associated with a University and the blood work was done in Slovakia. No PHDs or MDs among them. [1].

Digging deeper into their research method [2] the study looked at DNA breakage over a four month period in blood sampling for a coffee and non-coffee/caffeine group. I have a few questions about this, mainly around how effective the time period and method for determining total DNA stability. How many individual cell gnomes were measured in the before/after? What's the random variance for genome variability among cells in the same body? I suspect the variance is high enough to explain their unbelievably low p.

My guess is that the statistician is having fun with p-hacking [3] while collecting some funding from industry.

[0] https://en.wikipedia.org/wiki/Rosenthal-Bielatal

[1]https://link.springer.com/article/10.1007/s00394-018-1863-2

[2] https://www.mdlinx.com/journal-summaries/coffee-comet-assay-...

[3] http://psychology.wikia.com/wiki/P-hacking

Re:Consumption of a dark roast coffee blend reduces DNA dama... by rv-de on Wednesday January 16, 2019 @01:40AM (#18918737)
Also the study was ordered by Tchibo - a producer of dark roast coffee. What a coincidence. So naturally they didn't have an interest in finding that (assuming that the result is valid at all - which I doubt) tea with caffeine (or maybe just caffeine pills) has the same effect. Also why did they use a blend on earth? This study doesn't make sense on so many levels. But nobody diggs into it so it's successfully feeding the nutrition misinformation circle jerk.
Re:Consumption of a dark roast coffee blend reduces DNA dama... by pergadad on Wednesday January 16, 2019 @04:54AM (#18919518)
As you have access to the paper - do they take blood only once and compare the groups or do they they take 2+ times and compare the change? With such a small sample the first option would be very dubious.
Re:Consumption of a dark roast coffee blend reduces DNA dama... by sebbo on Wednesday January 16, 2019 @06:29AM (#18919926)
Right. At root, the protocol was not published and the outcomes were not prespecified, ergo this is dogshit.