I've typed Dvorak for a couple years, and have been quite happy with it. I'm curious about Colemak, though. Dvorak is pretty established as the alternative English-language keyboard layout - It's not hard to set up on Windows, Unix, or (I'm guessing) OS X. Is Colemak? While I'm convinced that Dvorak is significantly better than Qwerty, if you're the stubborn sort that would use a different keyboard layout for English (spoiler alert: I am), I suspect there's diminishing returns after that. Still, I'm really curious about Colemak (what was the rationale?) - I just don't know anybody who uses it.

My strategy of "heavily customized Emacs / Dvorak on my computers, standard Qwerty / vi otherwise" has been a good compromise over the years, incidentally.

Also, I work with Swedish hackers who remind me that Qwerty is only "standard" so far across the ocean. These things only make sense in a local context.