It depends on your needs... Are you building a complex application with several developers. You probably want a build system and module based JS. I prefer react + redux + material-ui. Some of the new stuff around hooks and context could displace redux for smaller apps easily.

If you need a one-off page that does a little dynamic stuff? Drop in jquery+bootstrap and a little wiring js and be done with it. Not a huge fan of the size of jquery + bootstrap, but it's a fast path to done depending on your one-off needs.