I think the more important misalignment between VCs and founders is a temporal one--if a VC thinks a company isn't going anywhere, they can immediately write it off and get on with their lives, whereas if a founder thinks her company isn't going anywhere, they have to (or think they have to!) "keep at it" until it goes bust. So they waste 2-5 of the most productive years of their most lives going through zombie motions.

Perhaps this perception is misplaced... I know VCs will say that they want a company to go bust as soon as possible (so that they aren't investing in Picplz). And this may be true.. but do you think a founder that had serially--and rapidly--gone bust 4/4 times 4 years in a row would get funding?