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Re:Warning Signs in Experimental Design and Interpretation (... by Larrikin on Monday January 07, 2019 @07:21PM (#18851738)
It seems that it would be unethical, for example, to make someone intentionally sick to mimic the side effects of the drug with none of the expected positive results.
Re:Warning Signs in Experimental Design and Interpretation (... by jfoutz on Monday January 07, 2019 @08:50PM (#18852332)
Yes. Yes it would. But comparing against baby aspirin might be worthwhile. There is some (safe?) effect beyond sugar pills.

Remember, the patients don’t know each other, and don’t compare symptoms. Hopefully.

Re:Warning Signs in Experimental Design and Interpretation (... by kranner on Monday January 07, 2019 @08:49PM (#18852323)
An expected physiological result can be just something like dry mouth or temporary diuresis. It doesn't have to go all the way to making a person e.g., nauseated.